NIH Reporter #PAR-21-274

Elucidating and Targeting tumor dependencies and drug resistance determinants at the single cell level

NIH grant awarded to Columbia University Health Sciences by the National Cancer Institute to study tumor dependencies and drug resistance at the single cell level, including development of drug sensitivity biomarkers and clinical trials.

Description

The project focuses on the elucidation and pharmacological targeting of Master Regulators (MRs) and Tumor Checkpoint (TC) modules at the single cell level. The project aims to develop drug sensitivity biomarkers and extend a network-based framework for tumor dependency targeting. The project involves clinical trials with tests like OncoTarget and OncoTreat.

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