Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK109714-09
Homeostatic Responses to Amino Acid Insufficiency
Recipient
Rutgers, The State University of New Jersey
Award Amount
$631,513.00
Ceiling
$631,513.00
Awarded
June 17, 2024
Identifier
5R01DK109714-09
NIH grant awarded to Rutgers University to study molecular mechanisms of amino acid insufficiency in mouse liver, focusing on pathways affecting liver health and metabolism.
Description
This project aims to uncover new mechanisms responsive to amino acid insufficiency in the liver of mice, addressing public health relevance aligned with NIH strategic goals for nutrition research. It investigates molecular pathways involving GCN2, mTORC1, and transcription factors such as ATF4, CHOP, and ATF5, to understand their roles in liver proteostasis, metabolism, and disease development.