Award
National Eye Institute 5R01EY034477-04
Back of the eye drug delivery: Novel contact lenses, pathways, and in-silico modeling
Recipient
Colorado School of Mines
Award Amount
$468,554.00
Ceiling
$468,554.00
Awarded
January 09, 2026
Identifier
5R01EY034477-04
NIH grant awarded to Colorado School of Mines for developing novel contact lenses for sustained drug delivery to the back of the eye, aiming to replace invasive injections.
Description
This project aims to develop and test novel contact lenses for delivering drugs to the back of the eye, focusing on mechanisms of drug delivery, modeling, and innovative lens designs. The project will involve in vitro, ex vivo, in vivo, and in silico studies, primarily using rabbit models. Key drugs include dexamethasone and anti-VEGF antibodies, with a focus on sustained release using vitamin E nanobarriers.