Award
NIH Reporter #5R21AI187937-02
Bile Resistance in Pseudomonas aeruginosa
Recipient
Northwestern University
Award Amount
$200,000.00
Ceiling
$200,000.00
Awarded
August 13, 2026
Identifier
5R21AI187937-02
NIH grant awarded to Northwestern University to study bile resistance mechanisms in Pseudomonas aeruginosa, focusing on genetic and transcriptomic methods to identify antimicrobial targets.
Description
This project aims to investigate the mechanisms of bile resistance in Pseudomonas aeruginosa, a major cause of healthcare-associated infections. The study will focus on the role of the sodium-hydrogen antiporter (shaA-F operon) in bile resistance, using genetic and transcriptomic approaches, including transposon insertion sequencing (INSeq) and RNA sequencing. The research will compare multiple strains to identify shared and strain-specific bile resistance pathways, with the goal of developing new antimicrobial targets.