Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 1R01AR083960-01A1
T-cell plasticity mediating treatment resistance and side effects in atopic dermatitis
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY, United States
Award Amount
$528,558.00
Ceiling
$528,558.00
Awarded
August 08, 2025
Identifier
1R01AR083960-01A1
NIH grant awarded to study immune mechanisms behind treatment resistance and side effects in atopic dermatitis patients treated with dupilumab, aiming to improve therapies.
Description
This NIH grant project aims to study treatment-resistant atopic dermatitis (AD) and paradoxical inflammatory skin side effects in patients treated with dupilumab to understand underlying mechanisms and develop better treatments. The study will use human skin biopsies and high-throughput techniques to analyze immune microenvironment features in different patient responses.