Award
National Cancer Institute 5R01CA282005-03
Developing New Treatment Strategies for Neuroendocrine Prostate Cancer
Recipient
University of Michigan at Ann Arbor
Award Amount
$544,206.00
Ceiling
$544,206.00
Awarded
April 17, 2026
Identifier
5R01CA282005-03
This NIH-funded project focuses on developing new treatment strategies for neuroendocrine prostate cancer by studying genetic mechanisms and creating targeted therapies to improve patient outcomes.
Description
The project aims to understand mechanisms by which loss of tumor suppressor genes TP53 and RB1 promotes NEPC development and to develop targeted combination therapies to inhibit NEPC cell survival. The research will explore how loss of these genes represses epithelial differentiation and activates NEPC pathways, with the goal of translating findings into clinical trials.