Award
NIH Reporter #5R61CA291117-03
Evolved Molecules that Destroy Cancer Relevant Proteins
Recipient
FOUNDATION FOR APPLIED MOLECULAR EVOLUTN
Award Amount
$369,207.00
Ceiling
$369,207.00
Awarded
August 27, 2026
Identifier
5R61CA291117-03
This award funds the development of innovative molecular reagents that can bind and destroy cancer-related proteins, focusing on PD-L1, to advance cancer diagnostics and therapies.
Description
The project aims to develop novel reagents (AEGISbodies and AEGISCleavers) that bind and cleave cancer-related proteins, specifically targeting Programmed Death-Ligand 1 (PD-L1) for potential applications in cancer diagnostics, targeted therapy, and protein engineering. These reagents will be stable against nucleases and capable of covalently tagging and destroying target proteins, with potential applications in diagnostics and therapeutics.