Award
National Institute of Allergy and Infectious Diseases 5R01AI153442-05
An experimentally-refined, dynamic gene regulatory network model of T-cell memory
Recipient
Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States
Award Amount
$633,135.00
Ceiling
$633,135.00
Awarded
February 13, 2025
Identifier
5R01AI153442-05
Award for developing a dynamic gene regulatory network model of T-cell memory to understand immune memory mechanisms and their implications for diseases and vaccines.
Description
This project aims to develop a dynamic gene regulatory network model of T-cell memory, integrating experimental genomics data with mathematical modeling to understand immune cell memory mechanisms. The research will focus on the epigenetic regulation of rapid recall in memory T cells, with potential implications for autoimmune diseases, allergies, cancer, and vaccine development.