Award
National Institute on Aging 4R01AG081362-02
Silencing of astrocytic MAGL as a therapy for Alzheimer’s disease
Recipient
University of Texas Health Science Center, San Antonio, TX
Award Amount
$771,678.00
Ceiling
$771,678.00
Awarded
March 09, 2026
Identifier
4R01AG081362-02
A gene therapy project targeting astrocytic MAGL to treat Alzheimer's disease by reducing neuroinflammation and neurodegeneration using AAV vectors.
Description
This project aims to develop a gene therapy targeting astrocytic MAGL to mitigate neuroinflammation and neurodegeneration in Alzheimer's disease. The approach involves AAV vector-mediated silencing of MAGL specifically in astrocytes, hypothesized to reduce AD neuropathology and preserve cognitive functions.