Award
NIH Reporter #5R01AR068128-10
Mechanisms and Function of Myonuclear Positioning
Recipient
Sloan-Kettering Institute for Cancer Research, New York, NY, United States
Award Amount
$547,414.00
Ceiling
$547,414.00
Awarded
January 28, 2025
Identifier
5R01AR068128-10
Research project funded by NIAMS to study mechanisms of myonuclear positioning in muscle cells to better understand muscle diseases and develop new treatment approaches.
Description
This project aims to identify mechanisms responsible for myonuclear movement and positioning, which are crucial for muscle function and are hallmarks of muscle disease. The research involves investigating signaling pathways at the myotendinous junction, the role of motoneurons, and the impact of mispositioned myonuclei on muscle function using human 3D muscle cultures co-cultured with motoneurons, advanced imaging, and genetic tools.