Award
National Institute of General Medical Sciences 5R35GM156405-02
Mechanisms regulating telomere length, protection and replication
Recipient
Yale University
Award Amount
$461,313.00
Ceiling
$461,313.00
Awarded
December 16, 2025
Identifier
5R35GM156405-02
Research project funded by NIGMS to study mechanisms of telomere length maintenance, protection, and replication using biochemical, structural, cellular, and genetic approaches, with implications for cancer and aging.
Description
The project aims to understand telomere biology, including protection, length regulation, and replication. Uses advanced biochemical, structural, cellular, and genetic techniques. Focuses on proteins such as POT1, TRF2-RAP1, BLM, ADAR1p110, Claspin. Developed novel assays like COMET-FISH. Implications for cancer and aging therapies.