Award
National Institute on Aging 1R21AG088504-01
Metabolic response to contraction in a 3D engineered muscle tissue model of aging
Recipient
University of Washington, Seattle, WA, United States
Award Amount
$485,375.00
Ceiling
$485,375.00
Awarded
August 30, 2024
Identifier
1R21AG088504-01
Research grant to study metabolic responses to muscle contraction in a 3D engineered muscle tissue model from aged human cells to understand sarcopenia mechanisms.
Description
Aging associated muscle loss, known as sarcopenia, involves dysfunctional mitochondria, altered metabolism, and reduced muscle function. Exercise and resistance training are among the few therapies that may slow or reverse sarcopenia. This project aims to establish a 3D engineered muscle tissue model from aged human cells to study metabolic responses to muscle contraction and identify molecular mechanisms involved in sarcopenia.