Award
NIH Reporter #5SC1NS127764-04
APE1 and Somatic Expansion in Huntington's Disease
Recipient
University of Puerto Rico Medical Sciences, San Juan, PR, United States
Award Amount
$327,094.00
Ceiling
$327,094.00
Awarded
March 21, 2025
Identifier
5SC1NS127764-04
Research project investigating APE1's role in delaying Huntington's Disease onset by preventing mitochondrial DNA damage and somatic expansion, aiming to identify new therapeutic targets.
Description
The project aims to investigate the role of APE1, a key enzyme involved in DNA repair, as a genetic modifier that may delay the age of onset of Huntington's Disease by preventing mitochondrial DNA damage and somatic expansion. The research explores the mechanistic functions of APE1 and mutant HTT in relation to HD onset, with implications for future drug discovery.