Award
NIH Office of the Director 5R01OD030496-05
Transformative rat models to study sex differences in disease
Recipient
University of California Los Angeles
Award Amount
$676,337.00
Ceiling
$676,337.00
Awarded
March 20, 2025
Identifier
5R01OD030496-05
NIH awarded $676,337 to develop genetically modified rat models to study sex differences in disease, focusing on isolating sex chromosome effects from hormonal effects, managed by UCLA.
Description
The project develops genetically modified rat models to study sex differences in disease by manipulating the Sry gene to create XX and XY rats with different gonads. It aims to measure physiological and cognitive parameters related to sex differences and isolate sex chromosome effects from hormonal effects. The models will be deposited in the Rat Resources & Research Center. The project is managed by the University of California Los Angeles and funded by NIH.