Award
NIH Reporter #5R01HL088256-16
Vesicular trafficking mechanisms regulating granulocyte function
Recipient
SCRIPPS RESEARCH INSTITUTE, THE, LA JOLLA, CA, UNITED STATES
Award Amount
$727,183.00
Ceiling
$727,183.00
Awarded
August 07, 2026
Identifier
5R01HL088256-16
This NIH grant supports research on molecular mechanisms of vesicular trafficking in neutrophils to understand and mitigate systemic inflammation and infection through targeted small-molecule inhibitors.
Description
Intracellular vesicular transport is essential for all aspects of neutrophil physiology and defects in this mechanism lead to disease in humans. The project aims to elucidate the molecular mechanisms regulating vesicular transport, exocytosis, phagocytosis, late endosomal maturation, and NETs production in neutrophils. It involves the development of small-molecule inhibitors targeting key regulators such as Rab27a-JFC1 and Munc13-4-STX7, and investigates their roles in systemic inflammation and infection models.