Award
National Institute of General Medical Sciences 5R01GM144632-04
High throughput platform to engineer light-controlled inhibitors against guanine exchange factors of the Dbl family
Recipient
Duke University
Award Amount
$358,077.00
Ceiling
$358,077.00
Awarded
September 09, 2025
Identifier
5R01GM144632-04
NIH awarded Duke University $358,077 to develop a high throughput platform for engineering light-controlled inhibitors targeting Dbl family guanine exchange factors, enabling precise control of cellular signaling in live cells.
Description
This NIH-funded project aims to develop optogenetic tools for precise control of GEF activity in live cells, facilitating advanced biological research. The project focuses on engineering light-controlled inhibitors against the Dbl family of guanine exchange factors to enable reversible inhibition with high spatial and temporal resolution.