Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR063709-10
Expanded fibroblast subset drives pathology in rheumatoid arthritis
Recipient
BRIGHAM AND WOMEN'S HOSPITAL
Award Amount
$261,776.00
Ceiling
$261,776.00
Awarded
August 28, 2025
Identifier
5R01AR063709-10
This NIH-funded project investigates the role of a specific fibroblast subset in driving inflammation and joint damage in rheumatoid arthritis, aiming to identify new therapeutic targets by studying fibroblast differentiation and Notch signaling pathways.
Description
Rheumatoid arthritis (RA) is a disease that affects the joints characterized by immune dysregulation resulting in chronic inflammation that damages cartilage and bone, potentially leading to permanent joint damage and disability. This project studies how fibroblast tissue cells in the joint regulate inflammation and drive joint damage in RA, aiming to identify new therapeutic targets.