Award
National Institute on Aging 4R01AG080742-02
Metabolic mechanisms of cognitive decline in aging and AD mediated by inflammatory PGE2 signaling
Recipient
Stanford University, CA, United States
Award Amount
$615,747.00
Ceiling
$615,747.00
Awarded
January 28, 2026
Identifier
4R01AG080742-02
Research project funded by the National Institute on Aging to study inflammatory PGE2 signaling's role in cognitive decline and Alzheimer's disease, aiming to develop therapeutic strategies by targeting peripheral immune pathways.
Description
The project investigates the role of inflammatory pathways driven by prostaglandin E2 (PGE2) and how peripheral inhibition of this pathway can restore cognitive function. The research aims to understand how metabolically reprogrammed myeloid cells in the periphery influence brain function, focusing on blood-brain barrier interactions, endothelial function, and astrocyte support of neurons.