# NIH Reporter #4DP2CA290244-02

Simulating Ancestrally Unbiased Tumor Evolution To Interrogate Drug Resistance

**Recipient:** University of California, San Francisco

**Award Amount:** $984,000.00
**Ceiling:** $984,000.00

**Awarded:** September 17, 2026

**Identifier:** 4DP2CA290244-02

The award supports research into how tumor ancestry and anatomic niches influence tumor evolution and drug resistance, using an organoid-based model to identify and test potential therapeutic targets.

### Description

Research project developing BRUTE, an immunocompetent organoid-based tumor graft system, to study ancestry-associated tumor evolution, drug resistance, and potential therapeutic targets.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11457478)