Award
National Institute of Allergy and Infectious Diseases 5K08AI168495-03
Establishing the impact of roseolovirues on development of autoimmunity due to loss of central tolerance
Recipient
Washington University, Saint Louis, MO, United States
Award Amount
$194,132.00
Ceiling
$194,132.00
Awarded
July 31, 2025
Identifier
5K08AI168495-03
This NIH-funded project investigates how roseoloviruses affect immune tolerance and contribute to autoimmune diseases by disrupting central tolerance mechanisms in the thymus.
Description
Murine roseolovirus (MRV) is a beta-herpesvirus genetically related to human roseoloviruses HHV-6 and HHV-7, associated with autoimmune disease. This project aims to define the mechanism by which roseoloviruses induce autoimmune disease through impact on central tolerance, focusing on thymic epithelial cell function and T cell receptor diversity.