Award
National Institute on Drug Abuse 5R01DA064083-02
Transcriptional inactivation of the CNS HIV reservoir with Tat-targeting lipid nanoparticles.
Recipient
Not specified
Award Amount
$703,675.00
Ceiling
$703,675.00
Awarded
June 03, 2026
Identifier
5R01DA064083-02
NIH awarded a project to develop lipid nanoparticles targeting CNS HIV reservoirs by inactivating the Tat gene using Cas9/sgRNA, with testing in animal models.
Description
This is a NIH project related to developing lipid nanoparticles targeting HIV reservoirs in the CNS, with a focus on Tat gene inactivation using Cas9/sgRNA. The project involves in vivo and ex vivo testing, including in mouse and macaque models.