Award
NIH Reporter #1ZIAHD008884-17
Neuronal Circuits Controlling Behavior: Genetic Analysis in Zebrafish
Recipient
Eunice Kennedy Shriver National Institute of Child Health and Human Development, United States
Award Amount
$2,186,181.00
Ceiling
$2,186,181.00
Awarded
April 27, 2024
Identifier
1ZIAHD008884-17
The award funds research on neuronal circuits in zebrafish to understand sensory processing, behavioral state control, and neurodevelopmental disorders, including modeling human mutations and testing therapeutic approaches.
Description
This project aims to understand central mechanisms controlling sensory processing, functional mapping of neuronal architecture mediating short-term behavioral states, and analysis of zebrafish models of neurodevelopmental disorders. It involves studying prepulse inhibition in zebrafish, identifying neural systems maintaining behavioral states, and generating zebrafish models for human neurodevelopmental mutations using CRISPR/Cas9. The project also explores therapeutic strategies for disorders such as Timothy syndrome using zebrafish models.