Award
National Institute of Allergy and Infectious Diseases 5R01AI175342-03
Studies of lipoamide dehydrogenase tight binding inhibition in tuberculous and non-tuberculous mycobacteria
Recipient
WEILL MEDICAL COLL OF CORNELL UNIV, NY, UNITED STATES
Award Amount
$594,241.00
Ceiling
$594,241.00
Awarded
November 25, 2025
Identifier
5R01AI175342-03
Research to develop tight binding inhibitors targeting mycobacterial lipoamide dehydrogenase to improve treatment of tuberculosis and non-tuberculous mycobacterial diseases, focusing on enzyme binding and in vivo efficacy.
Description
This project aims to develop inhibitors targeting mycobacterial lipoamide dehydrogenase (Lpd) to combat tuberculosis and non-tuberculous mycobacterial infections, focusing on structure-activity relationships and in vivo efficacy. The study explores the chemical biology of Mtb Lpd to develop tight binding inhibitors with improved efficacy, targeting multiple enzyme complexes in Mtb and extending to NTM pathogens such as Mycobacterium avium and M. abscessus.