Award
National Cancer Institute 5R01CA301410-31
Signal Transduction to P70 S6 Kinase 1
Recipient
Weill Medical College of Cornell University
Award Amount
$656,304.00
Ceiling
$656,304.00
Awarded
April 27, 2026
Identifier
5R01CA301410-31
The award funds research to elucidate molecular mechanisms regulating mTORC1 signaling in cancer, focusing on GSK3, SRPK2, and dietary fatty acids to identify new therapeutic targets.
Description
This project aims to understand the molecular regulation of mTORC1 signaling pathways involved in cancer cell growth, metabolism, and resistance to therapy. The research focuses on the roles of GSK3 nuclear signaling, SRPK2 kinase, and dietary fatty acids in modulating mTORC1 activity, with the goal of identifying new therapeutic targets and biomarkers for personalized cancer treatment.