Award
National Heart, Lung, and Blood Institute 5F30HL172628-02
Therapeutic potential of CC-90009 for cystic fibrosis
Recipient
University of North Carolina at Chapel Hill
Award Amount
$41,184.00
Ceiling
$41,184.00
Awarded
August 27, 2025
Identifier
5F30HL172628-02
This award supports research on CC-90009 as a potential therapy for cystic fibrosis, focusing on its effects on CFTR function and ENaC activity to improve lung function in patients with specific genetic variants.
Description
The project investigates the therapeutic potential of CC-90009, a thalidomide derivative, which promotes ribosomal readthrough to rescue PTC-CFTR variants and reduces ENaC activity, aiming to improve mucociliary transport in CF and other lung diseases.