Award
NIH Reporter #1K99NS146570-01
Exploring Cholinergic Changes and their Associations with Sleep Alterations in the Lewy Body Disease Spectrum: New Biomarkers and Therapeutic Targets
Recipient
University of Michigan at Ann Arbor, MI, United States
Award Amount
$128,358.00
Ceiling
$128,358.00
Awarded
February 16, 2026
Identifier
1K99NS146570-01
NIH grant awarded to University of Michigan to study cholinergic changes affecting sleep in Lewy Body Disorders, aiming to identify new biomarkers and therapeutic targets using advanced imaging and sleep monitoring technologies.
Description
This NIH grant project investigates cholinergic brain activity's role in regulating sleep, particularly REM sleep, in humans. It focuses on Lewy Body Disorders, including Parkinson's disease and Dementia with Lewy Bodies, exploring cholinergic changes and their impact on sleep disturbances such as REM sleep behavior disorder (RBD). The study uses PET radiotracers and wearable sleep recording devices to identify new biomarkers and therapeutic targets.