Award
National Institute of General Medical Sciences 5R35GM125028-09
The assembly and function of cellular contractile systems
Recipient
Vanderbilt University, Nashville, TN
Award Amount
$475,500.00
Ceiling
$475,500.00
Awarded
January 27, 2026
Identifier
5R35GM125028-09
This NIH grant supports research on cellular contractile systems, specifically myosin II-based mechanisms, to understand force generation in cell processes and disease contexts.
Description
Research grant focused on determining the mechanisms by which myosin II-based contractile systems assemble to provide a mechanistic understanding of force-dependent pathological processes leading to diseases such as cancer and cardiovascular disease. The research aims to develop a detailed and predictive model of how contractile systems generate force to drive cell division, cell movement, and muscle contraction, distinguishing mechanisms used by normal vs. aberrant cells.