Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK077148-13
Metabolic and xenobiotic control of thyroid hormone metabolism
Recipient
University of Texas Med Br Galveston
Award Amount
$423,748.00
Ceiling
$423,748.00
Awarded
February 24, 2026
Identifier
5R01DK077148-13
This award funds research on how neonatal thyroid hormone signaling influences DNA methylation in the liver, affecting gene expression and susceptibility to metabolic diseases like obesity and liver steatosis in adulthood.
Description
Neonatal thyroid hormone signaling in the liver modifies the future susceptibility to liver steatosis and obesity. This is explained by differential DNA methylation affecting gene expression in the adult liver. The project explores how the neonatal peak of thyroid hormone signaling affects DNA methylation and physiological consequences.