Award
National Institute of Allergy and Infectious Diseases 5R01AI170189-05
Development of Allogeneic CAR T Cell Therapy for a Functional Cure of HIV Infection
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$471,626.00
Ceiling
$471,626.00
Awarded
April 02, 2026
Identifier
5R01AI170189-05
The project focuses on developing an allogeneic CAR T cell therapy to achieve a functional cure for HIV by enhancing persistence, efficacy, and resistance to allorejection.
Description
This study aims to develop HIV-specific allogeneic chimeric antigen receptor (CAR) T cells capable of evading recipient allorejection and controlling HIV replication in the absence of ART, towards a functional cure for HIV.