Award
National Institute on Aging 5R01AG089561-03
Role of EphA1/A2 domain-domain and -membrane interactions for receptor specificity and Blood Brain Barrier dysfunction
Recipient
CASE WESTERN RESERVE UNIVERSITY
Award Amount
$805,356.00
Ceiling
$805,356.00
Awarded
July 09, 2026
Identifier
5R01AG089561-03
NIH-funded research project investigating Eph receptor interactions and their impact on blood brain barrier dysfunction and neurodegenerative diseases, with goals to develop diagnostic and therapeutic tools.
Description
This project aims to identify key residues in Eph receptor interactions crucial for their functional states, focusing on EphA2 and related receptors, to understand their role in blood brain barrier dysfunction and neurodegenerative diseases such as Alzheimer's Disease. The research will provide structural insights for developing diagnostic and therapeutic agents targeting neuronal and vascular diseases.