Award
NIH Reporter #1R35GM163509-01
The Structure and Function of a Eukaryotic Centromere
Recipient
University of North Carolina at Chapel Hill, Department of Biology
Award Amount
$528,497.00
Ceiling
$528,497.00
Awarded
July 29, 2026
Identifier
1R35GM163509-01
This award funds research to understand the physical structure and function of eukaryotic centromeres, using computational and bioimaging techniques to study chromosome segregation mechanisms.
Description
The project investigates the physical structure of centromere chromatin, focusing on the organization into a stiff spring that resists microtubule pulling forces during mitosis. It employs computational modeling and advanced bioimaging to explore the role of chromatin bottlebrushes organized by condensin and cohesin proteins in building tension between sister kinetochores.