Award
NIH Reporter #5R01GM157608-03
DMS/NIGMS 2: The mathematics of epigenetic regulation in human cells
Recipient
University of Texas Dallas, Richardson, TX
Award Amount
$274,153.00
Ceiling
$274,153.00
Awarded
August 21, 2026
Identifier
5R01GM157608-03
This award funds research to model epigenetic regulatory networks in human cells by combining theoretical, computational, and experimental methods. The project aims to understand epigenetic mechanisms and their dynamic behaviors, advancing knowledge in developmental biology and medicine.
Description
A project to develop accurate and predictive models of epigenetic mechanisms in human cells using theoretical, computational, and experimental approaches. The project involves assembling and integrating epigenetic regulators and circuits in human cells, characterizing their dynamic behavior and stability, developing methods for large DNA cassette integration, and modeling stochastic gene expression kinetics to predict multistability, phase transitions, and oscillations.