Award
National Institute of Allergy and Infectious Diseases 5R01AI168047-04
Role for nuclear matrix proteins and DNA methylation for XCI maintenance in female lymphocytes
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$528,479.00
Ceiling
$528,479.00
Awarded
June 08, 2026
Identifier
5R01AI168047-04
This NIH grant supports research on the role of nuclear matrix proteins and DNA methylation in maintaining X chromosome inactivation in female lymphocytes, aiming to understand female-biased lupus disease mechanisms.
Description
The project investigates molecular mechanisms specific to female B cells that regulate gene expression on the inactive X chromosome, and how alterations in these pathways impair B cell function and increase lupus disease severity in mice. The findings aim to reveal genes predisposed to epigenetic alterations and aberrant expression for female-biased lupus disease.