Award
National Institute of General Medical Sciences 2R35GM136239-06
Peptide Processing by Copper Enzymes
Recipient
Oregon Health & Science University, Portland, OR, USA
Award Amount
$619,006.00
Ceiling
$619,006.00
Awarded
March 19, 2026
Identifier
2R35GM136239-06
The NIH grant supports research on copper enzyme-mediated peptide processing, focusing on mechanisms of peptide amidation and crosslinking to advance understanding of biologically active peptides relevant to therapeutics.
Description
This project aims to understand the reaction chemistry of metal-mediated peptide processing pathways via detailed mechanistic studies on two classes of copper-dependent enzymes: PHM (amidation) and AhyBURP (peptide crosslinking). The research involves electronic structural studies, exploration of enzyme reaction chemistry with substrate analogues, and cryo-EM studies of related enzymes.