Award
National Heart, Lung, and Blood Institute 11169374
Platelet-Mediated Neutrophil Extracellular Traps Regulate Ischemic Stroke Injury
Recipient
Washington University, Saint Louis, MO
Award Amount
$549,049.00
Ceiling
$549,049.00
Awarded
April 24, 2025
Identifier
11169374
Research project funded by the National Heart Lung and Blood Institute to study the role of neutrophil extracellular traps in ischemic stroke and evaluate a novel inhibitor for therapeutic potential.
Description
This project investigates the role of neutrophils and platelets in ischemic stroke injury, focusing on neutrophil extracellular traps (NETs) and their regulation by platelet-derived HMGB1. The study aims to determine if targeting NET formation with a novel endogenous inhibitor (nNIF) can improve stroke outcomes.