Award
National Cancer Institute 5R01CA298456-02
The STAT3 Pathway in Uterine Leiomyoma: A Therapeutic Target
Recipient
Northwestern University
Award Amount
$651,337.00
Ceiling
$651,337.00
Awarded
December 18, 2025
Identifier
5R01CA298456-02
Research project funded by the National Cancer Institute to study the STAT3 pathway's role in uterine fibroid growth and evaluate STAT3 inhibitors as potential therapies.
Description
This project aims to investigate the role of the STAT3 pathway, which is hyperactivated by MED12 mutations, in fibroid growth. The research will explore how disruption of Mediator kinase activity influences STAT3 activity and promotes tumor growth. The study will utilize patient-derived xenograft models and cutting-edge single-nucleus multiomics to elucidate the pathway's role and identify potential therapeutic targets.