National Cancer Institute 5R01CA273123-04

Investigating and modeling MYD88L265P and co-occurring mutations in mature B-cell malignancies

A research project funded by the National Cancer Institute to study the role of MYD88L265P mutation and co-occurring genetic alterations in B-cell lymphomas, developing mouse models for therapy testing.

Description

This project aims to investigate the molecular mechanisms by which MYD88L265P mutation, Chr6q deletion, and other genomic alterations induce lymphomagenesis in B-cell lymphomas, with the goal of advancing diagnosis, prognosis, and therapy development. It involves generating transgenic mice to study these mutations and develop preclinical models for testing therapies.

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