Award
NIH Reporter #5F32AI181301-03
Characterizing host translation inhibition by Legionella pneumophila
Recipient
Johns Hopkins University, Baltimore, MD
Award Amount
$81,580.00
Ceiling
$81,580.00
Awarded
July 06, 2026
Identifier
5F32AI181301-03
Research project investigating how Legionella pneumophila inhibits host cell translation via effector proteins, focusing on the effector SidL and its activity during infection.
Description
This project aims to determine the mechanism of one effector, SidL, and establish a framework for when various translation-inhibiting effectors are active during infection by Legionella pneumophila. The research includes a comprehensive temporal analysis of translation inhibition during the Legionella infection cycle, which lasts approximately 24 hours. The findings could provide insights into Legionella's pathogenic mechanisms and reveal new aspects of host cell biology.