Award
National Heart, Lung, and Blood Institute 5R01HL179780-02
Gut Microbe-Derived Lipids Shape Chronic Inflammation in Cardiometabolic Disease
Recipient
Cleveland Clinic Lerner College of Medicine (CLEVELAND)
Award Amount
$728,435.00
Ceiling
$728,435.00
Awarded
March 04, 2026
Identifier
5R01HL179780-02
The award funds research on the role of gut microbe-derived lipids in chronic inflammation related to cardiometabolic diseases, aiming to explore microbial metabolite-host receptor interactions and develop novel therapeutic approaches.
Description
This project investigates how gut microbe-derived lipids called N-acyl amides influence chronic inflammation in cardiometabolic diseases such as obesity, diabetes, and atherosclerosis. The research focuses on the microbial metabolite N-oleoyl serinol signaling via the host receptor GPR119 to suppress metainflammation, with the goal of developing probiotic therapies and understanding therapeutic potential in cardiometabolic disease.