Award
National Cancer Institute 5U54CA283114-03
Deciphering the Dynamic Evolution of the Tumor-Neural Interface
Recipient
Massachusetts Institute of Technology
Award Amount
$428,797.00
Ceiling
$428,797.00
Awarded
September 22, 2025
Identifier
5U54CA283114-03
NIH/NCI funded research project at Massachusetts Institute of Technology to model tumor evolution and tumor-neuronal interactions in glioblastoma using multi-omics and computational-experimental frameworks.
Description
The project focuses on high-content systems-level measurements at molecular, microscopic, and macroscopic scales with spatial resolution to develop computational models for tumor dynamics in glioblastoma. It aims to identify signaling and metabolic pathways regulating tumor progression and resistance, and to understand the tumor-neuronal interface, including glioma cell networks and synaptic connectivity, to inform therapeutic strategies.