Award
National Institute on Alcohol Abuse and Alcoholism 2P50AA024337-11
Effect of alcohol on microbiome-gut-brain axis and neuropathology and memory dysfunction in Alzheimer's disease
Recipient
University of Louisville
Award Amount
$282,600.00
Ceiling
$282,600.00
Awarded
July 10, 2026
Identifier
2P50AA024337-11
Research grant studying how alcohol affects Alzheimer's disease progression through gut microbiome changes, testing tributyrin as a treatment.
Description
This project evaluates the interactive effects of heavy alcohol drinking and Alzheimer's disease pathogenesis at the level of gut dysbiosis and the development of neuropathological changes and memory deficit. It uses a mouse model to examine the effects of chronic alcohol on Alzheimer's disease development and tests the efficacy of tributyrin as a potential intervention.