Award
National Institute on Aging 5R01AG080565-03
Brain mitochondrial PET imaging and 31P-MR spectroscopy to dissect the role of mitochondrial dysfunction in bioenergetic dysregulation in Dementia with Lewy Bodies pathogenesis
Recipient
University of Pittsburgh at Pittsburgh, PA, United States
Award Amount
$1,679,694.00
Ceiling
$1,679,694.00
Awarded
July 16, 2025
Identifier
5R01AG080565-03
Research project funded by the National Institute on Aging to study mitochondrial dysfunction in Dementia with Lewy Bodies using brain imaging and spectroscopy to understand bioenergetic dysregulation and its role in disease pathogenesis.
Description
This project aims to characterize mitochondrial respiratory chain dysfunction, dissect bioenergetic pathways contributing to ATP dysregulation, analyze the relationship between mitochondrial dysfunction and cognitive changes, and compare bioenergetic pathway dysfunction between Dementia with Lewy Bodies and Alzheimer’s disease using advanced neuroimaging techniques.