Award
National Institute of General Medical Sciences 5R01GM143400-04
Single-component optogenetic tools to bidirectionally control RhoA in mechanotransduction
Recipient
University of Pennsylvania
Award Amount
$346,770.00
Ceiling
$346,770.00
Awarded
August 15, 2025
Identifier
5R01GM143400-04
The award funds research to develop optogenetic tools for controlling RhoA signaling to study cell mechanics and motility, relevant to tissue engineering and regenerative medicine.
Description
This project aims to engineer, benchmark, and demonstrate the unique capabilities of an optogenetic toolbox to bi-directionally (activation and inactivation) control RhoA signaling to advance fundamental understanding of cell contractility, motility, and mechanotransduction.