Award
National Institute of Mental Health 5R01MH128021-05
Targeting HIV Myeloid Reservoirs in the CNS by IAP and TREM1 Inhibition
Recipient
University of South Dakota, Vermillion, SD, United States
Award Amount
$373,750.00
Ceiling
$373,750.00
Awarded
April 12, 2025
Identifier
5R01MH128021-05
This award funds research to develop therapies targeting HIV reservoirs in the central nervous system by inhibiting proteins that help infected cells survive, aiming to cure HIV.
Description
The project aims to develop a new therapeutic strategy to eradicate HIV-1 by focusing on how HIV upregulates host proteins to avoid apoptosis and promote cell survival, specifically targeting macrophages and microglia resistant to viral cytopathicity. The approach involves inhibiting inhibitor of apoptosis proteins (IAPs) and TREM1 to induce apoptosis of HIV-infected microglia without affecting uninfected cells, potentially leading to HIV cure.