Award
National Heart, Lung, and Blood Institute 5R01HL180433-02
Real-Time, Non-Invasive Thrombus Characterization using Ultrasound Responsive Nanodroplets
Recipient
University of Michigan at Ann Arbor
Award Amount
$763,283.00
Ceiling
$763,283.00
Awarded
August 06, 2026
Identifier
5R01HL180433-02
Development of a real-time, non-invasive method to characterize thrombus age and mechanical properties using ultrasound-responsive nanodroplets.
Description
This project aims to develop an in situ micro-rheology technique using ultrasound-responsive nanodroplets that phase-transition into microbubbles via acoustic droplet vaporization (ADV). These bubbles' acoustic emissions will be correlated with thrombus age and elastic modulus to enable real-time, non-invasive characterization of thrombi.