Award
National Institute of Mental Health 5F30MH134471-02
Investigating the role of the medial orbitofrontal cortex (mOFC) in negative reinforcement learning
Recipient
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Award Amount
$54,538.00
Ceiling
$54,538.00
Awarded
August 20, 2025
Identifier
5F30MH134471-02
This NIH-funded fellowship project studies the medial orbitofrontal cortex's role in negative reinforcement learning in mice to understand compulsive behaviors in OCD, using advanced neural analysis techniques.
Description
The project involves investigating the cellular- and circuit-level mechanisms of negative reinforcement learning in mice, focusing on the medial orbitofrontal cortex (mOFC). The project aims to provide insights into how aberrant mOFC activity may contribute to compulsive behaviors in OCD. It includes use of microendoscopy, optogenetics, and neural circuit analysis. The project is funded by the NIH as part of a fellowship program and is led by Brittany Lynn Chamberlain, MD/PHD Student at the University of Pittsburgh.