Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK138673-03
How NTS NPY neurons alter NTS circuitry to promote food intake
Recipient
Washington State University
Award Amount
$514,223.00
Ceiling
$514,223.00
Awarded
February 19, 2026
Identifier
5R01DK138673-03
This award funds research to study how NPY neurons in the NTS brain region regulate food intake and how their activity changes with metabolic states, aiming to inform obesity treatments.
Description
The research focuses on the circuitry of the Nucleus of the Solitary Tract (NTS) in the brainstem, particularly NPY-expressing neurons, which influence food intake. The study aims to understand how these neurons are activated, how they influence other NTS neurons, and how their activity changes with metabolic states such as fasting and high-fat high-sugar diets. The findings are expected to elucidate critical neural circuits involved in food intake regulation and contribute to improved therapeutic strategies for obesity.