Award
National Institute of Diabetes and Digestive and Kidney Diseases 2R01DK107733-10A1
Regulation of Nutrient Homeostasis by COMMD proteins
Recipient
UT Southwestern Medical Center
Award Amount
$713,910.00
Ceiling
$713,910.00
Awarded
February 16, 2026
Identifier
2R01DK107733-10A1
NIH grant awarded to UT Southwestern Medical Center to study molecular mechanisms of copper regulation and homeostasis, focusing on the CCC complex and its role in copper metabolism and related diseases.
Description
This project aims to uncover the molecular mechanisms regulating copper (Cu) excretion and homeostasis, focusing on the role of the CCC complex and its interacting factors in late endolysosomal vesicles. The study involves biochemical, cellular, and animal model research to elucidate how the CCC complex influences ATP7A/B trafficking and Cu metabolism, with potential implications for diseases such as Wilson’s disease.