Award
National Institute of General Medical Sciences 5R35GM144043-05
Genetic Dissection of Germ Cell Differentiation and Function
Recipient
UT Southwestern Medical Center
Award Amount
$488,952.00
Ceiling
$488,952.00
Awarded
February 17, 2026
Identifier
5R35GM144043-05
The NIH grant supports research on germ cell biology using Drosophila as a model, focusing on genome stability, differentiation, and molecular regulation with advanced genetic tools, aiming to impact human health understanding.
Description
This project uses the Drosophila ovary as a model to gain insights into genome stability, germ cell differentiation, and regulation of mRNA translation and ribosome biogenesis. The research involves innovative CRISPR-Cas9 and recombineering methods to manipulate the Drosophila genome, with over 100 genes mutated or tagged. The focus includes characterizing the GCNA gene, Rbfox1 control in germ cell development, and developing tools to assess ribosome biogenesis during germ cell development and embryogenesis. The work aims to advance understanding of germ cell biology and its implications for human health.