Award
NIH Reporter #1RF1AG087271-01A1
Mapping amyloid, tau, and neurodegeneration markers with neuropsychiatric phenotypes and genotypes in Alzheimer's disease continuum using machine learning
Recipient
Washington University, Saint Louis, MO, United States
Award Amount
$3,188,901.00
Ceiling
$3,188,901.00
Awarded
August 26, 2025
Identifier
1RF1AG087271-01A1
A research project funded by the National Institute on Aging to study Alzheimer's disease using machine learning on neuroimaging and genetic data to understand neuropsychiatric symptoms and heterogeneity in the disease.
Description
This project aims to leverage in-vivo ATN markers from amyloid PET, tau PET, and MRI to investigate the multivariate relationships between these markers and neuropsychiatric phenotypes and genotypes in Alzheimer's disease. It utilizes large-sample data from multiple cohorts and applies machine learning predictive modeling and heterogeneity analytics to understand neuropsychiatric aspects of Alzheimer's disease and contribute to precision medicine in diagnosis and treatment.